NIH StrokeNet Acute Trials

Multi-Arm Optimization of Stroke Thrombolysis Stroke Trial (MOST)
Location: University of Virginia
Purpose: The goal of this study is to determine the effectiveness of combining a drug known as tissue plasminogen activator, or tPA, with blood thinners argatroban or eptifibatide.  The research will look at whether combining tPA with either argatroban or eptifibatide will produce better results in stroke patients in the first 90 days after suffering a stroke versus tPA with a placebo.
The plan is for 110 hospitals to take part in the study through NIH StrokeNet, the University of Cincinnati based National Coordinating Center for all stroke trials funded by the National Institute of Neurological Disorders and Stroke. 
Contact: S. Iris Deeds, CCRP at 513-558-8627

MNRH Acute Trials

Neuroplasticity in Hand Function Recovery After Stroke
Purpose: When do patients show high neuroplasticity after stroke? Can we improve recovery using post-stroke neuroplasticity?
Inclusion Criteria: Age > 18, ischemic stroke, <30 days ago or healthy volunteers with no other neurological issues.
Contact: Shashwati Geed, PhD, 202-877-1131 or

Brain-based Understanding of Individual Language Differences after stroke (BUILD)
Purpose: To help us understand why recovery from stroke is different for each individual stroke survivor.
Inclusion Criteria: >18 years, left hemisphere stroke, no other neurological issues, able to have an MRI.
Contact Person: Elizabeth Lacey, PhD, 202-877-1124 or

Functional Arm use after Stroke (FAST)
Purpose: Improve the use of accelerometry as a tool to measure arm use after stroke.
Inclusion Criteria: >18 years, stroke occurred > 1 year OR newly admitted to inpatient rehab continue to to experience arm weakness.
Contact Person: Abby Mitchell, OTR/L 202-877-1464 or