Project Description for Professionals

Critical Periods after Stroke Study
Location: MedStar National Rehabilitation Hospital
Purpose: To perform an exploratory single center randomized study that will form the basis for a larger scale, more definitive randomized clinical trial to determine the optimal time after stroke for intensive motor training.
Learn More: https://clinicaltrials.gov/ct2/show/NCT02235974?term=CPASS&rank=1

Ethnic/Racial Variations in Intracerebral Hemorrhage (ERICH)
Location: MedStar Georgetown University Hospital
Purpose: The purpose of this study is to find risk factors for hemorrhagic stroke, specifically intracerebral hemorrhage (ICH), among Caucasians, African Americans, and Hispanics.
Learn More: https://clinicaltrials.gov/ct2/show/NCT01202864?term=ERICH&rank=2

Stroke Hyperglycemia Insulin Network Effort (SHINE)
Location: MedStar Washington Hospital Center
Purpose: The Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial is a multicenter, randomized, controlled clinical trial of 1400 patients that will include approximately 60 enrolling sites. The study hypotheses are that treatment of hyperglycemic acute ischemic stroke patients with targeted glucose concentration (80mg/dL - 130 mg/dL) will be safe and result in improved 3 month outcome after stroke.
Learn More: https://clinicaltrials.gov/ct2/show/NCT01369069?term=SHINE&rank=2

MR WITNESS: A Study of Intravenous Thrombolysis With Alteplase in MRI-Selected Patients
Location: MedStar Washington Hospital Center, MedStar Georgetown University Hospital
Purpose: This study was jointly developed and is jointly led by investigators at Massachusetts General Hospital and the intramural division of NINDS. We are doing this research study to find out if Activase ® (also called alteplase or rt-PA) can safely be given to people with an acute ischemic stroke when their stroke onset was not witnessed making them ineligible for standard thrombolytic (clot busting) therapy. We also want to find out if rt-PA can help people recover better from their stroke.
Learn More: https://clinicaltrials.gov/ct2/show/NCT01282242?term=MR+Witness&rank=1

Study of Procoagulation Markers in Stroke Patients (I-SPOT)
Location: MedStar Washington Hospital Center
Purpose: The Insights on Selected Procoagulation Markers and Outcomes in Stroke Trial (I-SPOT): Response to Insulin Administration and Blood Glucose Control proposal is designed to accompany the Stroke Hyperglycemia Insulin Network Effort (SHINE) clinical trial, a Phase III multicenter, randomized, controlled trial planning to determine the efficacy and validate the safety of glycemic control in stroke patients.
Learn More: https://clinicaltrials.gov/ct2/show/NCT01811550?term=I-SPOT&rank=1